Respiratory Disease in Practice

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Chronic irritant exposures and asthma
RDIP, Volume 18, Number 3.

In 1985, Brooks and colleagues described ten subjects who developed persisting asthma following a single, brief, high-level exposure to an inhaled ‘irritant’.1 The wheezing began within 24 hours of the exposure, and often immediately. The authors coined the term Reactive Airway Dysfunction Syndrome (RADS) and devised diagnostic criteria (Table 1).

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