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Antileukotriene drugs in asthma therapy RDIP, Volume 15, Number 4.
Leukotrienes (LTs) are potent pro-inflammatory mediators produced by different cells including mast cells, basophils, eosinophils and macrophages.1 Following cellular activation, arachidonic acid is released from membrane phospholipids by the action of phospholipase A2 and subsequently metabolised by the enzyme 5-lipoxygenase to produce LTs. This includes LTC4, LTD4 and LTE4, also known as cysteinyl LTs by virtue of containing a cysteine residue.
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